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Darren Baker

Molecular biologist at Mayo Clinic.

The research interests of Darren J. Baker, M.S., Ph.D., are focused on the involvement of senescent cells in the processes of aging and cancer.

Cellular senescence, a state of irreversible cell cycle arrest that limits the ability of cells to divide, is a potent anti-tumor mechanism that is also a common feature of aged tissue. Instead of simply being resident cells within a tissue, senescent cells promote various age-related phenotypes due to components that they secrete.

Studying the role of cellular senescence in vivo, however, has been difficult due to the lack of reliable markers and the inability to selectively manipulate these cells in animals.

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See also: Health Organisation Mayo Clinic - Non-profit American academic medical center focused on health care, education, and research

Details last updated 15-Jan-2020

Darren Baker is also referenced in the following:

Healthy Ageing (Virtual Conference)

25-May-2022 to 27-May-2022

Virtual conference by Wellcome Connecting Science with Judith Campisi as a keynote speaker

Darren Baker News

Senolytics staves off dementia in mice

Guardian - 19-Sep-2018

Killing of senescent (aging) brain cells with an enzyme stopped the progress of dementia


Clearing the Body’s Retired Cells Slows Aging and Extends Life

The Atlantic - 03-Feb-2016

Cells accumulate damage in their DNA. Eventually become senescent – i.e. they stop dividing – an...


Secret to old age health could lie in purging worn-out cells

New Scientist - 16-Sep-2015

Cells eventually stop dividing to replace damaged neighbours and to into senescence. Senescent c...