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Christopher Wiley

Research Assistant Professor at Buck Institute for Research on Aging

Dr. Wiley’s research focuses on the study of aging in the context of cellular metabolism, particularly as it pertains to the process known as cellular senescence. Cellular senescence is a stress response by which cells adopt a state of permanent mitotic arrest. More than simple arrest, the senescent phenotype is complex and includes a senescence-associated secretory phenotype (SASP) that leads to secretion of multiple biologically active molecules, including proinflammatory cytokines, matrix metalloproteinases, and growth factors, that can have potent effects on the tissue microenvironment. Recently, a series of advancements have placed both senescence and the SASP at center stage with regard to variegated maladies associated with aging. Despite these advancements, senescence is still studied largely in the context of replicative exhaustion, genotoxic stress, or oncogene activation, all of which result in highly similar senescent phenotypes.

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See also: Institute Buck Institute - Independent biomedical research institute focused on aging

Christopher Wiley News

First ever non-invasive biomarker test to detect senolysis

Buck Institute - 02-Apr-2021

Detectible senescence-specific biomarker allows development of new drugs for age-related conditions

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Nature Biotechnology reviews the state of play of senolytics

Nature Biotechnology - 12-Nov-2020

In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...

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Senescent cells amplify blood clotting - now protein targets identified

Buck Institute - 24-Sep-2019

Could help tackle venous thrombosis that becomes a bigger risk with age

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