Dr. Wiley’s research focuses on the study of aging in the context of cellular metabolism, particularly as it pertains to the process known as cellular senescence. Cellular senescence is a stress response by which cells adopt a state of permanent mitotic arrest. More than simple arrest, the senescent phenotype is complex and includes a senescence-associated secretory phenotype (SASP) that leads to secretion of multiple biologically active molecules, including proinflammatory cytokines, matrix metalloproteinases, and growth factors, that can have potent effects on the tissue microenvironment. Recently, a series of advancements have placed both senescence and the SASP at center stage with regard to variegated maladies associated with aging. Despite these advancements, senescence is still studied largely in the context of replicative exhaustion, genotoxic stress, or oncogene activation, all of which result in highly similar senescent phenotypes.