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Aging and rejuvenation - a modular epigenome model

Research paper on rejuvenation and aging published in the Aging Journal - led by Rodolfo Goya

Abstract

The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.

Authors of this paper are Priscila Chiavellini, Martina Canatelli-Mallat, Marianne Lehmann, Maria D. Gallardo, Claudia B. Herenu, Jose L. Cordeiro, James Clement and Rodolfo G. Goya.

Visit website: https://www.aging-us.com/article/202712/text

See also: Academic Rodolfo Goya - Senior Investigator at the Institute for Biochemical Research, Argentina (INIBIOLP-UNLP)

Details last updated 04-Mar-2021

Mentioned in this Resource

Claudia B. Herenu

Researcher in Farmacology Department at National University of Cordoba.

James W. Clement

Author, lawyer and entrepreneur turned research scientist

José Cordeiro

Engineer, economist, futurist, and transhumanist

Maria Delfina Gallardo

Doctoral Fellow at the National University of La Plata.

Marianne Lehmann

Research fellow at Institute for Biochemical Research (INIBIOLP).

Martina Canatelli-Mallat

Research fellow at Institute for Biochemical Research (INIBIOLP).

Priscila Chiavellini

Research fellow at Institute for Biochemical Research (INIBIOLP).

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Topics mentioned on this page:
Rejuvenation, Epigenetics