Prof. Dr. Adam Antebi’s research group focuses on how evolutionarily conserved signal transduction pathways, hormonal mechanisms, and metabolism impact development and longevity in the nematode Caenorhabditis elegans. Such new insights into mechanisms that regulate lifespan may lead to innovative approaches to improve human health into old age.

Prof. Adam Antebi and his research team focus on the effects of the endocrine system and metabolism on development and life span. Using the nematode C. elegans as a model organism, they unravel the molecular mechanisms of how dietary restriction extends health and life span. They also investigate how hormonal signals from the reproductive system alter animal development and longevity. Finally they explore how metabolism and quality control mechanisms impact maintenance of cellular organelles and organismal survival. From a molecular perspective they examine the influence of steroids, insulins and micro-RNAs on animal longevity. Additionally they explore how activation of the hexosamine pathway and other metabolic pathways stimulate protein quality control, which protects cells within the organism from age-related proteotoxicity and neurodegeneration.