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Kwang-Soo Kim

South Korean neuroscientist, McLean Hospital

Kwang-Soo Kim, PhD, has over 25 years of experience investigating molecular and developmental neurobiology of the midbrain dopamine neuronal system in health and disease, focusing on elucidating the transcriptional mechanisms underlying development and maintenance of dopamine neurons. Based on basic transcriptional studies of midbrain dopamine neurons, Dr. Kim’s lab identified the orphan nuclear receptor Nurr1 as a potential drug target of Parkinson’s disease (PD) to develop novel drug candidates for neuroprotective and mechanism-based therapeutics. Promising compounds are being generated using established high throughput screening by medicinal chemistry and are being tested in preclinical animal models.

Dr. Kim’s lab also investigates translational stem cell research and personalized cell therapy of PD and is optimizing reprogramming and differentiation methods. His lab has pioneered the generation of clinical grade induced pluripotent stem (iPS) cells using non-viral reprogramming methods such as direct delivery of reprogrammed proteins and novel episomal methods, and has recently identified novel mechanisms underlying metabolic reprogramming during human induced pluripotency.

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See also: Health Organisation McLean Hospital - Psychiatric hospital, affiliate of Harvard Medical School

Kwang-Soo Kim News

Parkinson's patient can swim again after stem cell transplant

Newsweek - 14-May-2020

Study and procedure represent a milestone in personalized medicine for Parkinson's


Successful replacement of neurons lost in Parkinson's disease

Medical Xpress - 13-May-2020

New therapeutic personalized strategy could bring back movement to those suffering