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Secondary stroke damage due to sticky pileup in blood vessels

Exosomes pick-up platelets causing blockage as seen in animal model

15-Jan-2020

Key points from article :

Traveling exosomes after stroke get activated, sticky, and accumulates on blood vessels lining.

Platelets adhere to these causing more buildup that obstruct brain blood flow.

RGD sequences are key contributor to the secondary damage from stroke.

Synthetic exosomes seen as future treatment option.

αvβ3 receptors become key sites for cells to pile up inside the blood vessel.

Research by Medical College of Georgia and University of Oxford, published in Nature.

Mentioned in this article:

Click on resource name for more details.

Augusta University

Public Research University and medical center in Georgia

Daniel C. Anthony

Professor of Experimental Neuropathology/Pharmacology, Department of Pharmacology, University of Oxford

Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Scientific Reports

Scientific Journal providing information from all areas of the natural sciences

University of Oxford

Collegiate research university and one of the world's leading universities

Zsolt Bagi

Vascular biologist, MCG Department of Physiology, Augusta University, Jan20

Topics mentioned on this page:
Stroke