Join the club for FREE to access the whole archive and other member benefits.

Overcoming the odds of bile duct cancer with experimental immunotherapy

A 51-year-old patient in trial is now cancer-free with immunotherapy drug and chemotherapy

30-Dec-2022

Key points from article :

A 51-year-old welder diagnosed with advanced stage intrahepatic bile duct cancer, and had spread to his adrenal gland.

He joined a clinical trial of an experimental immunotherapy drug, combined with standard chemotherapy at The Christie.

Tumour in his liver shrunk from 12cm to 2.6cm, while the one in his adrenal gland shrank from 7cm to 4.1cm.

During the operation, surgeons found only dead tissue, which meant the treatment had killed off all the cancer cells.

Since his operation, he had no further treatment and his three-monthly scans showed he was completely clear of cancer.

"Robert has done very well on this combination due to his tumour having... a high number of genetic mutations," - Juan Valle, researcher.

"Most patients with this diagnosis do not have as many mutations in their cancer cells, so the treatment won't be as effective, but it does highlight the importance of personalised medicine."

Mentioned in this article:

Click on resource name for more details.

Juan Valle

Professor of Medical Oncology in the University of Manchester

The Christie NHS Foundation Trust

NHS Foundation Trust in Manchester

Topics mentioned on this page:
Cancer
Overcoming the odds of bile duct cancer with experimental immunotherapy