Key points from article :
Enochian Biosciences presented at the Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT).
Novel approach to potentially cure HIV uses genetic modification of cells to overexpress enzyme ALDH1.
This protected them from dying when they were treated with low doses of a chemotherapeutic drug, cyclophosphamide.
164% increase in engraftment of transplanted cells in a mouse model.
Two people have been cured of HIV following transplantation of cells, from another person, with genetic mutations that prevent HIV infection.
Increase in engraftment of genetically modified and transplanted cells in the bone marrow of mice could lead to a clinical approach.
Novel approach killed up to 97 percent of cells infected with hepatitis B virus in vitro.
New in vivo studies describe the mechanism of action of that killing.
"[Drug therapies risk] non-compliance that can lead to HIV and HBV viral resistance" - Carol Brosgart, UCSF and a member of the Enochian Board of Directors.
