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Deep learning techniques identified compounds that kill MRSA in mice

Promising advance in antibiotics with potential to combat a major health threat

20-Dec-2023

Key points from article :

Using deep learning, MIT researchers identified compounds that kill drug-resistant MRSA bacteria.

They developed methods to understand how the AI makes its predictions, aiding future drug design.

From 12 million compounds, the AI picked 5 classes likely effective against MRSA.

These antibiotics disrupt a key bacterial function, different from existing drugs.

Researchers are refining these candidates and using the AI to find antibiotics for other bacteria.

Published in Nature, the study demonstrated the compounds' ability to kill MRSA in lab dishes and two mouse models with low toxicity to human cells, making them promising drug candidates.

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Massachusetts Institute of Technology (MIT)

Private land-grant research university

Nature

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Topics mentioned on this page:
Antibiotic Resistance, AI in Healthcare
Deep learning techniques identified compounds that kill MRSA in mice