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Bacteria-eating viruses fight drug resistant superbugs in a non-healing wound


Key points from article :

A women developed a superbug infection on her left thigh.

Infected with two strains of Klebsiella pneumoniae, one of which exhibited a drug-resistant phenotype.

Wound failed to heal after nearly two years of antibiotic treatments.

Samples were sent to the George Eliava Institute of Bacteriophages, Microbiology and Virology.

Identified a phage that could efficiently infect and kill the patient's K. pneumoniae strains.

Phages were trained to kill specific bacteria very effectively, through a process called pre-adaptation.

Showed improvement within two days of starting phage therapy, she was also switched to a newly-available antibiotic against drug-resistant K. pneumoniae, - Anaïs Eskenazi, the study's first author.

After three months, there were no signs of the superbug and her wound was steadily healing.

After three years, patient has regained mobility; bacterial infection has not returned.

Case report by CUB-Erasmus hospital published in the journal Nature Communications.

When antibiotics fail, bacteriophages can heal -- clinical trials need to confirm this treatment approach

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Anaïs Eskenazi

Specialist in internal medicine and infectious disease at CUB-Erasmus hospital

George Eliava Institute of Bacteriophages, Microbiology and Virology

Nonprofit research institute in the field of bacteriophages and its applications

Nature Communications

Journal covering all topics in physics, chemistry, and biology.