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A new class of drugs to tackle AMR - immuno-antibiotics

23-Dec-2020

Key points from article :

A new class of antibiotics promote a rapid immune response with an antibacterial action.

Bacteria are becoming resistant to treatment with all available antibiotic options.

"We reasoned that harnessing the immune system to simultaneously attack bacteria on two different fronts makes it hard for them to develop resistance," - Dr. Dotiwala, lead author.

Focused on the MEP pathway that is essential for most bacteria but absent in humans.

Targeted the IspH enzyme involved in this pathway to kill the microbes.

Computer modelling screened commercially available compounds to select the most potent ones.

In preclinical models the bactericidal effects of the selected IspH inhibitors outperformed traditional antibiotics.

All compounds tested were shown to be nontoxic to human cells.

Research by The Wistar Institute published in Nature.

Block an essential metabolic pathway in bacteria to combat antimicrobial resistance (AMR)

Mentioned in this article:

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Academic

Assistant professor in the Vaccine & Immunotherapy Center at The Wistar Institute

Journal

Scientific journal covering all aspects of the natural sciences relating to questions of biological significance.

Institute

Independent institution devoted to biomedical research and training