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A green tea compound helps fight cancer via p53 interaction

12-Feb-2021

Key points from article :

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein.

"EGCG is able to boost p53's anti-cancer activity, opening the door to drugs with EGCG-like compounds," - Chunyu Wang, corresponding author.

P53 has several anti-cancer functions - halting cell growth, activating DNA repair, and initiating programmed cell death.

EGCG is a natural antioxidant, found in abundance in green tea.

It helps to undo the near constant damage caused by using oxygen metabolism.

p53 is quickly degraded when the N-terminal domain interacts with a protein called MDM2.

This regular cycle of production and degradation holds p53 levels at a low constant.

"When EGCG binds with p53, the protein is not being degraded through MDM2....more p53 for anti-cancer function," - Wang.

Study by Rensselaer Polytechnic Institute published in the Journal Nature Communications.

Antioxidant compound in green tea improves p53 levels and insights offer new approach to cancer therapies

Mentioned in this article:

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Academic

Professor of Biological Sciences and Chemistry and Chemical Biology at Rensselaer Polytechnic Institute

Journal

Journal covering all topics in physics, chemistry, and biology.

Academia

Private research university in Troy, New York