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A green tea compound helps fight cancer via p53 interaction


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An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein.

"EGCG is able to boost p53's anti-cancer activity, opening the door to drugs with EGCG-like compounds," - Chunyu Wang, corresponding author.

P53 has several anti-cancer functions - halting cell growth, activating DNA repair, and initiating programmed cell death.

EGCG is a natural antioxidant, found in abundance in green tea.

It helps to undo the near constant damage caused by using oxygen metabolism.

p53 is quickly degraded when the N-terminal domain interacts with a protein called MDM2.

This regular cycle of production and degradation holds p53 levels at a low constant.

"When EGCG binds with p53, the protein is not being degraded through MDM2....more p53 for anti-cancer function," - Wang.

Study by Rensselaer Polytechnic Institute published in the Journal Nature Communications.

Antioxidant compound in green tea improves p53 levels and insights offer new approach to cancer therapies

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Professor of Biological Sciences and Chemistry and Chemical Biology at Rensselaer Polytechnic Institute


Journal covering all topics in physics, chemistry, and biology.


Private research university in Troy, New York