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A Diabetes drug brings dramatic weight loss in obese patients


Key points from article :

A weekly injection of semaglutide was given alongside advice on diet and fitness.

2,000 people showed an average 15kg weight loss during the 15-month trial.

Some use it as a treatment for type 2 diabetes, but this trial looked at giving it at higher doses.

Hijacking body's appetite levels and mimicking a hormone GLP1.

32% of people lost a fifth of their body weight with the drug, compared with fewer than 2% on dummy treatment.

"Losing weight would reduce the risk of heart disease, diabetes and of severe Covid-19," - Rachel Batterham, professor at UCL.

Would be used initially by specialist weight loss clinics.

Side-effects include nausea, diarrhoea, vomiting, and constipation.

"Amount of weight loss is greater than that seen with any licensed anti-obesity drug." - Stephen O'Rahilly, Physician-scientist.

"...any medication or change in lifestyle can bring potential risks and side-effects." - Duane Mellor, dietician.

Study by UCL published in the New England Journal of Medicine.

Semaglutide suppresses appetite, helping trail participants lose 20% of their weight

Mentioned in this article:

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Clinical dietitian and associate dean education - quality enhancement at Aston University


Professor of Obesity, Diabetes & Endocrinology at University College London


Head of the Department of Clinical Biochemistry at the University of Cambridge


Scientific Journal devoted to medical research.


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