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A Diabetes drug brings dramatic weight loss in obese patients


Key points from article :

A weekly injection of semaglutide was given alongside advice on diet and fitness.

2,000 people showed an average 15kg weight loss during the 15-month trial.

Some use it as a treatment for type 2 diabetes, but this trial looked at giving it at higher doses.

Hijacking body's appetite levels and mimicking a hormone GLP1.

32% of people lost a fifth of their body weight with the drug, compared with fewer than 2% on dummy treatment.

"Losing weight would reduce the risk of heart disease, diabetes and of severe Covid-19," - Rachel Batterham, professor at UCL.

Would be used initially by specialist weight loss clinics.

Side-effects include nausea, diarrhoea, vomiting, and constipation.

"Amount of weight loss is greater than that seen with any licensed anti-obesity drug." - Stephen O'Rahilly, Physician-scientist.

"...any medication or change in lifestyle can bring potential risks and side-effects." - Duane Mellor, dietician.

Study by UCL published in the New England Journal of Medicine.

Semaglutide suppresses appetite, helping trail participants lose 20% of their weight

Mentioned in this article:

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Duane Mellor

Clinical dietitian and associate dean education - quality enhancement at Aston University

Rachel Batterham

Professor of Obesity, Diabetes & Endocrinology at University College London

Stephen O’Rahilly

Head of the Department of Clinical Biochemistry at the University of Cambridge

The New England Journal of Medicine

Scientific Journal devoted to medical research.

University College London (UCL)

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