In this episode, David A. Sinclair, PhD, AO, joins the show. A Professor of Genetics at Harvard Medical School and Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, Sinclair has been recognized by Time magazine as one of the “100 most influential people in the world.” He is renowned for his pioneering research on resveratrol, NAD, and reprogramming to reverse ageing, earning him over 35 prestigious awards.

Key Points:

David A. Sinclair shares ground-breaking insights into the science of ageing and the potential to significantly extend human lifespans. His research emphasizes the importance of lifestyle and emerging therapies in resetting the ageing process.

• Ageing Predictions: Sinclair predicts that by 2030, children born today could live to an average of 104 years, with potential advancements pushing lifespans even further.
• The Role of Lifestyle: 80% of lifespan is determined by lifestyle factors such as diet and exercise, while only 20% is genetic. This means we have significant control over our ageing process.
• Longevity Genes: Sinclair highlights the importance of longevity genes like sirtuins, AMP kinase, and mTOR, which protect our bodies from ageing. These genes are influenced by lifestyle and can be activated by molecules like NAD boosters.
• Intermittent Fasting: One of Sinclair's key recommendations is intermittent fasting—skipping one or two meals a day to activate longevity genes and potentially extend lifespan.
• NAD Boosters: He discusses the use of NAD-boosting supplements, which have shown promising results in animal studies, such as increasing endurance in mice. However, he advises caution due to the experimental nature of these supplements.
• Future of Age Reduction: Sinclair foresees a future where clinics offering age-reduction treatments will become mainstream, and doctors will routinely prescribe medications like metformin for ageing prevention.