Prof. Valery Krizhanovsky is Incumbent of the Karl and Frances Korn Career Development Chair in Life Sciences. Department of Molecular Cell Biology, Weizmann Institute of Science

Prof. Valery Krizhanovsky’s research is focused on understanding of the role of cellular senescence in physiological and pathophysiological conditions.

Prof. Krizhanovsky was one of the pioneers to study the role of cellular senescence in tissue damage and repair and the interaction of senescent cells with the immune system. Recently Krizhanovsky’s laboratory discovered a novel mechanism of interaction of senescent cells with other cells that regulates the immune surveillance of senescent cells. Research at Krizhanovsky’s laboratory showed presence of cellular senescence in the placenta; thus providing, together with other laboratories, the first evidence that senescence can play a role in embryonic development. Recent studies at the laboratory discovered mechanisms that regulate the viability of senescent cells. Inhibition of these pathways allowed elimination of senescent cells in vivo.