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The Hallmarks of Aging

Research on hallmarks of aging with special emphasis on mammalian aging

This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging.

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.

Visit website: https://www.cell.com/cell/fulltext/S0092-8674(13)00645-4

See also: Academic Carlos Lopez-Otin - Professor in the Department of Biochemistry and Molecular Biology at the University of Oviedo.

Details last updated 09-Apr-2019

Topics mentioned on this page:
Ageing Research