In this AMA (Ask Matt Anything) session, longevity scientist Matt Kaeberlein takes on audience questions about hormone therapy, anti-aging drugs, health scans, and nutrition trends. From testosterone injections to the hype around time-restricted eating, he offers a practical, evidence-based look at some of today’s most debated longevity interventions.

Key Points:

The episode wraps with lighter moments—like Guinness in Dublin pubs—reminding listeners that longevity science is about balance, not extremes. This AMA emphasizes context, measurement, and moderation when considering hormones, drugs, or diets for health and longevity. Evidence matters, and simple lifestyle fundamentals often outweigh trendy shortcuts.

• Testosterone Therapy Choices : Matt explains why he opted for injectable testosterone over oral or gel forms, outlining pros, cons, and personal experiences with dosing, delivery methods, and side effects.
• Women, Stress & Hormones : Chronic stress and restrictive dieting can disrupt hormone balance in women. Testosterone therapy may help maintain muscle mass and mood, but always needs regular hormone monitoring.
• Rapamycin in Real Life : While animal studies suggest anti-aging effects, evidence in humans (especially under age 40) is limited. Matt discusses risks, dosing strategies, side effects like lipid changes, and why cycling might make sense for some.
• Diet Myths Debunked : Time-restricted eating alone doesn’t show strong benefits unless tied to calorie reduction. Not all processed foods are equally harmful; quality and moderation matter more than rigid rules.
• Health Monitoring Tools : From DEXA scans to full-body MRIs, Matt clarifies what each test actually measures, when they are useful, and why over-testing can sometimes backfire.