Sebastien Uzel
Research Associate at the Wyss Institute.
His research is focused on the mechanical properties of collagen. This material, present in the human body under different forms (mostly from type I to type IV) at various sites (bones, tendons, skin, cartilage, cornea...), demonstrates interesting behavior.
At the nanoscale, he's investigating the local stiffness and toughness of the collagen molecule using MD simulations, the effects of mutations in the sequence of amino-acids and the applications in better understanding genetic diseases such as osteogenesis imperfecta or Ehlers-Danlos syndrome. At the mesoscale, a bottom-up approach will enable to create a refined continuum model and link the amount of cross-links and hydroxyapatite crystals to the risk of failure.
Visit website: https://web.mit.edu/mbuehler/www/group/uzel.html
See also:
Wyss Institute
- Research institute focused on developing bioinspired materials and devices
Details last updated 07-Nov-2019
Sebastien Uzel News
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