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Patricia Opresko

Associate Professor in Department of Environmental and Occupational Health at the University of Pittsburgh

My lab studies DNA damage and repair at telomeres. Telomeres are the caps at chromosome ends that are essential for preserving the genome. When chromosomes lose their telomere caps the cells age and this contributes to the onset of degenerative diseases with aging. If chromosomes lose their telomere caps in pre-cancerous cells then this causes genetic alterations that hasten the progression to cancer. Understanding how telomere damage and repair happens should lead to new intervention strategies aimed at preserving these regions of the genome that are so critical for protecting our chromosomes and maintaining youthful cells.

Visit website: http://www.opreskolab.com/

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 Opreskolab

See also: Academia University of Pittsburgh - Public state-related research university

Details last updated 11-Jun-2019

Patricia Opresko News

New insight on the accumulation of senescent cells in humans

UPMC - 30-Jun-2022

Oxidative DNA damage induce rapid senescence compared with shorter telomeres from repeated cell divisions

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Direct oxidative stress on telomeres leads to faster cellular ageing

News Medical - 14-May-2019

Prevents uncontrolled cell division in cancer cells

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Articles written by Patricia Opresko

Direct oxidative stress on telomeres leads to faster cellular ageing

News Medical - 14-May-2019

Prevents uncontrolled cell division in cancer cells

Read more...