Patricia Opresko
Associate Professor in Department of Environmental and Occupational Health at the University of Pittsburgh
My lab studies DNA damage and repair at telomeres. Telomeres are the caps at chromosome ends that are essential for preserving the genome. When chromosomes lose their telomere caps the cells age and this contributes to the onset of degenerative diseases with aging. If chromosomes lose their telomere caps in pre-cancerous cells then this causes genetic alterations that hasten the progression to cancer. Understanding how telomere damage and repair happens should lead to new intervention strategies aimed at preserving these regions of the genome that are so critical for protecting our chromosomes and maintaining youthful cells.
Visit website: http://www.opreskolab.com/
See also: University of Pittsburgh - Public state-related research university
Details last updated 11-Jun-2019
Patricia Opresko News
New insight on the accumulation of senescent cells in humans
UPMC - 30-Jun-2022
Oxidative DNA damage induce rapid senescence compared with shorter telomeres from repeated cell divisions
Read more...Direct oxidative stress on telomeres leads to faster cellular ageing
News Medical - 14-May-2019
Prevents uncontrolled cell division in cancer cells
Read more...Articles written by Patricia Opresko
Direct oxidative stress on telomeres leads to faster cellular ageing
News Medical - 14-May-2019
Prevents uncontrolled cell division in cancer cells
Read more...