At the Longevity Summit Dublin 2024, Maria Marinova delivered a keynote focusing on the role of NAD+ repletion in rescuing fertility and promoting health in post-menopausal and chemotherapy-treated women. Her research shows the significant potential of NAD+ supplementation in restoring ovarian function, enhancing bone density, and improving overall healthspan. She emphasized the need for careful dosing and further research into its broader applications​.

Key Points:

• Reproductive Ageing and Healthspan: Maria Marinova discussed the rapid decline of ovarian function with age and its significant impact on women's healthspan. Menopause increases the risk of diseases like cardiovascular issues, and ovarian ageing may also influence overall lifespan.
• NAD+ in Fertility Restoration: Marinova presented research demonstrating that NAD+ repletion can restore fertility in ageing female mice. Supplementation improved ovulation rates, oocyte quality, and overall reproductive outcomes, particularly in older females.
• Effects of Chemotherapy: Marinova highlighted that chemotherapy drastically diminishes fertility by damaging rapidly dividing cells in the ovaries. However, NAD+ supplementation helped restore fertility and improved follicle health post-chemotherapy.
• Bone Health and Late-Life Benefits: In addition to fertility, NAD+ repletion was found to enhance bone health in ageing mice, improving bone density and strength. This suggests broader applications of NAD+ in promoting overall healthspan and combating osteoporosis post-menopause.
• Dosing Concerns: Marinova cautioned that the effectiveness of NAD+ depends on the correct dosage. In her research, lower doses of NAD+ showed positive effects, while higher doses were ineffective, indicating a need for further study on optimal dosing.
• Impact on Offspring Health: Marinova also explored the effects of maternal NAD+ supplementation on offspring health, finding no adverse impacts and even some beneficial outcomes, such as increased lean body mass in the offspring.