In this episode, Dr. Rhonda Patrick explores the critical role of NAD⁺ — a molecule essential for energy production, DNA repair, and longevity — and how its levels decline with age. She breaks down how precursors like NR and NMN, often called “NAD⁺ boosters,” are being studied for their potential to restore NAD⁺ and reverse ageing-related dysfunctions in tissues such as the brain, muscle, and heart.

Key Points:

Dr. Patrick emphasizes that while NAD⁺ boosters show significant potential, especially in preclinical settings, more evidence is needed on their long-term safety and efficacy in humans. Until then, lifestyle interventions remain the most reliable and accessible ways to support healthy NAD⁺ levels and promote longevity.

• NAD⁺ and Ageing: NAD⁺ is essential for life and declines with age, contributing to DNA damage, metabolic slowdown, and disease.
• What Are NAD⁺ Boosters?: NR and NMN are precursors shown in animals to raise NAD⁺ levels and improve organ function at high doses.
• Mechanism and Limitations: Most NAD⁺ in the body comes from recycling; oral boosters often rely on this pathway and may face feedback limits.
• Promising but Cautious Human Data: Human trials show NR can raise NAD⁺ in blood cells, but long-term benefits and optimal doses remain unclear.
• Potential Risks and Practical Use: In specific cancers, NAD⁺ boosters may worsen outcomes; storage and formulation also affect supplement quality.