In this episode, Matt and Brian Kennedy explore the promises and pitfalls of interventions like Rapamycin, emphasizing the importance of biomarkers and strategies for improving healthspan and cognitive function. They discuss challenges in ageing research, including supplement use, regulatory barriers like the FDA’s view on ageing, and the complexities of research methodologies.

Key Points:

This episode delves into critical topics in ageing research, from cutting-edge interventions like Rapamycin to the role of lifestyle factors in extending healthspan. Matt and Dr. Brian Kennedy share a dynamic discussion on the intersection of science and health, focusing on interventions, biomarkers, and personalized approaches to healthy ageing.

• Rapamycin and Ageing: The conversation highlights Rapamycin's growing popularity in longevity science, with intermittent dosing showing promise in enhancing healthspan. They address potential side effects, like mouth sores, and stress the need for more comprehensive clinical trials.
• Lifestyle's Role in Cognitive and Overall Health: Fundamental lifestyle habits—regular exercise, a nutrient-rich diet, quality sleep, and stress management—are emphasized as foundational for maintaining cognitive function and overall health. Addressing specific deficiencies, such as omega-3 fatty acids, can provide additional benefits.
• Biomarkers as Ageing Indicators: The speakers explore the value of biomarkers, such as blood-based ageing clocks and other health metrics, in assessing biological age and tailoring interventions. They caution against over-reliance on unproven or commercially marketed tests.
• Thoughtful Approach to Supplements: They caution against taking multiple supplements without clear evidence of their efficacy, suggesting a measured, experimental approach to supplementation. They highlight the importance of tracking health metrics to evaluate outcomes.
• AI’s Transformative Potential in Ageing Science: Artificial intelligence is positioned as a game-changer for analysing vast datasets and identifying effective ageing interventions. However, the speakers stress the need for high-quality, diverse training data to maximize AI's impact.
• Combatting Chronic Inflammation: Chronic sterile inflammation is identified as a significant driver of ageing. Anti-inflammatory strategies, such as healthy diets, fasting, exercise, and targeted therapies like Rapamycin, are recommended to mitigate its impact and promote healthspan.