In this episode, Matt and Nick discuss three recent geroscience findings on pregnancy, exercise, and diet. The first study suggests that women who have been pregnant age faster than those who haven't, based on six epigenetic clocks. The second links evening workouts to reduced cardiovascular and all-cause mortality risks in adults with obesity. The third, presented at an American Heart Association meeting, highlights a connection between time-restricted eating and lower heart disease mortality. They explore the studies' limitations, potential mechanisms, and the need for further research on healthspan and longevity.

Key Points:

This episode covers three recent geroscience findings: pregnancy accelerates ageing according to epigenetic clocks, evening workouts benefit cardiovascular and all-cause mortality in adults with obesity, and time-restricted eating reduces heart disease risk. Matt and Nick discuss study limitations, underlying mechanisms, and future research needed for deeper insights.

• Pregnancy and biological ageing: Research suggests pregnancy may accelerate biological ageing based on epigenetic markers, but these effects may reverse postpartum. The long-term implications are still unclear​.
• Evening workouts and mortality: A study found that exercising in the evening significantly reduces the risk of death, particularly in individuals with a high BMI and type 2 diabetes​.
• Intermittent fasting and heart disease risk: A controversial study linked eating within an 8-hour window to a higher risk of heart disease mortality, but it lacks causation evidence and has many confounding factors​.
• Epigenetic clocks: Various epigenetic clocks were used to measure biological age, showing mixed results in terms of pregnancy's impact on ageing​.
• Workout timing for health: While evening workouts showed benefits in certain groups, there’s no definitive evidence that time of day significantly affects overall exercise outcomes​.
• Concerns about diet studies: The hosts discuss how studies like those on intermittent fasting may overlook diet quality, lifestyle, and other factors that affect long-term health​.