Somatic mutations: Do these DNA changes hold the secrets to longevity?
Live Forever Club - 31-Mar-2024The gradual buildup of DNA mutations may hold clues on how to combat age-related diseases
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Group at the University of Liverpool led by Joao Pedro de Magalhaes
An important element of our work is the development of tools and methods for aiding research on the biology and genetics of ageing, in particular computational tools like databases and algorithms. These are made available on the Human Ageing Genomic Resources (HAGR). Most notably, HAGR features various three genetic databases: 1) GenAge, a manually-curated database of genes related to ageing in humans and model organisms; 2) the LongevityMap, a database of human genetic variants associated with longevity; and 3) the GenDR database of genes associated with the life-extending effects of dietary restriction in model organisms. For comparative and evolutionary studies of ageing, we developed AnAge, a database of ageing and longevity in animals featuring over 4,000 species. Bioinformatics tools and software are also available on HAGR in the form of Perl scripts and an SPSS script for demographic analyses. HAGR has been featured in Science (307:187) and Nature Reviews Genetics (5:1362), among other journals, and its resources have been cited hundreds of times.
Joao Pedro de Magalhaes moved to Birmingham, with his lab now called Rejuvenomics
Visit website: https://pcwww.liv.ac.uk/~aging/
See also: University of Liverpool - Public research university for UK and international students
Details last updated 06-Sep-2019
The gradual buildup of DNA mutations may hold clues on how to combat age-related diseases