Hansen Professor of Structural Biology Chair Department of Integrative Structural and Computational Biology.

Immunologic recognition of microbial pathogens is fundamental for fighting infectious disease. Our major goal is to understand the interaction and neutralization of foreign antigens by the immune system through high-resolution x-ray structural studies of antibodies, Variable Lymphocyte Rectors (VLRs) and antigens in the humoral system, T-cell receptor complexes with MHC class I and class II in the cellular system, and through pattern recognition receptors, such as TLRs, in the innate immune system.