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Small molecule oral drug could treat influenza A


Key points from article :

Scripps Research has discovered an drug that neutralizes influenza A group 1 viruses.

Covers many of the seasonal flu strains, and also pandemic strains, such as H1N1 and H5N1.

JNJ-4796 is an orally active small molecule drug.

Recognizes the HA stem in the same way as the antibody.

Protected mice infected with 25 times the normally-lethal dose of H1N1 influenza.

Small molecules are cheaper, more shelf-stable, and are more convenient for patients.

The study was published in Science journal.

Targets seasonal and pandemic strains of flu

Mentioned in this article:

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Hansen Professor of Structural Biology at Scripps Research Institute.


Pharmaceutical company which is part of Johnson & Johnson company.


Peer-reviewed academic online journal of the American Association for the Advancement of Science (AAAS)


Medical research facility with focus on research and education in the biomedical sciences.