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Small molecule oral drug could treat influenza A

Targets seasonal and pandemic strains of flu

11-Mar-2019

Key points from article :

Scripps Research has discovered an drug that neutralizes influenza A group 1 viruses.

Covers many of the seasonal flu strains, and also pandemic strains, such as H1N1 and H5N1.

JNJ-4796 is an orally active small molecule drug.

Recognizes the HA stem in the same way as the antibody.

Protected mice infected with 25 times the normally-lethal dose of H1N1 influenza.

Small molecules are cheaper, more shelf-stable, and are more convenient for patients.

The study was published in Science journal.

Mentioned in this article:

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Ian Wilson

Hansen Professor of Structural Biology at Scripps Research Institute.

Janssen Pharmaceutical

Pharmaceutical company which is part of Johnson & Johnson company.

Science

Peer-reviewed academic online journal of the American Association for the Advancement of Science (AAAS)

Scripps Research Institute

Medical research facility with focus on research and education in the biomedical sciences.

Topics mentioned on this page:
Pandemics
Small molecule oral drug could treat influenza A