Join the club for FREE to access the whole archive and other member benefits.

Emily Burnside

Post Doc at German Center for Neurodegenerative Diseases (DZNE).

My PhD project involves investigating plasticity and synaptogenesis after spinal cord injury (SCI) and potential therapeutic use of chondroitinase. Chondroitinase ABC has been shown to promote midline sprouting in the intact corticospinal tract (CST), associated with functional improvement after SCI. My main project will utilise a rodent unilateral pyramidotomy model, comprising a one-sided lesion of the CST at the level of the medullary pyramids, allowing study of plasticity in the intact CST. I will be using genetically encoded reporters of presynaptic function, which represent novel tools to assess synaptogenesis and gain insight into the anatomical and functional status of new connections immunohistochemically, following unilateral pyramidotomy and intraspinal delivery of a ChABC lentiviral vector. An additional property of one of the reporters is pH-dependent fluorescence upon exocytosis. This tool will eventually be utilised in an ex vivo electrophysiology slice preparation.

Visit website: https://kclpure.kcl.ac.uk/portal/emily.burnside.html

 Login to view link, or join the club to get full access to all resources and other benefits.

 Login to view link, or join the club to get full access to all resources and other benefits.

See also: Academia King's College London - Public research university

Emily Burnside News

Gene therapy reverses rat's paralysis

BBC - 14-Jun-2018

Study used virus to deliver genetic information that reduced scar tissue in the spinal cord

Read more...