In this episode, Matt and Nick discussed the recent Interventions Testing Program experiments on longevity, which sparked a lively debate on X. Charles Brenner from City of Hope raised concerns about rapamycin's effects, while Mike Muldoon of Ponce De Leon Health promoted Rejuvant, despite tests showing no lifespan extension in mice. Matt responded on X, leading to a thought-provoking exchange.

Matt and Nick break down the feedback, analysing data to address the claims and discussing the need for critical thinking when encountering terms like "scientifically proven" in marketing.

Key Points

Matt and Nick review expert feedback on longevity interventions and emphasize the need for critical evaluation of "scientifically proven" marketing claims.

• NAD Precursor Supplements: The podcast discusses how NAD precursors like Resveratrol, Metformin, and Fisetin, tested in the Interventions Testing Program (ITP), failed to show lifespan extension, raising questions about their effectiveness.
• Rapamycin Debate: A significant portion of the discussion focuses on rapamycin's impact on muscle mass and quality of life, with contrasting views on whether it might degrade or improve human health.
• Misleading Claims: The podcast critiques misleading information in the longevity space, emphasizing the need for accurate representation of scientific data, particularly around supplements like NAD precursors.
• Rejuvant and Clinical Proof: The hosts question claims about the efficacy of supplements like Rejuvant (calcium alpha-ketoglutarate), pointing out the importance of robust, reproducible data before making strong claims about health benefits.
• Role of Social Media: The conversation touches on the degradation of productive discussions in the longevity space on platforms like Twitter, where debates often devolve into sales pitches or unproductive arguments.
• Scientific Rigor: A recurring theme is the importance of scientific rigor and skepticism, especially when evaluating new supplements or treatments purported to extend lifespan or improve health.