T cells engineered to target and remove damaged cells in mice
Medical News Today - 31-Jan-2024The treated mice showed better health, including improved metabolism and activity
Join the club for FREE to access the whole archive and other member benefits.
Assistant Professor at Cold Spring Harbor Laboratory
Corina joined Cold Spring Harbor Laboratory as an Independent Fellow in January 2022. The CSHL Fellows program offers promising young investigators the opportunity to establish their own research group shortly after completing graduate work. Corina received an M.D. from Universidad Complutense de Madrid in Spain in 2017 and then enrolled in the Gerstner Sloan Kettering Graduate School at Memorial Sloan Kettering Cancer Center in NY where she earned a Ph.D conducting her doctoral research in the laboratory of Scott W Lowe. Her thesis work focused on developing immune-based strategies to target senescent cells. This included studies to identify surface markers of senescent cells, pioneering the use of CAR T cells as senolytics and the development of flexible somatic cancer mouse models. Her work on senolytic CAR T cells was widely highlighted in leading journals in the field and earned her the Chairman’s Prize Award from Memorial Sloan Kettering. In 2022 Corina established her own research group whose goal is to study cellular senescence in cancer and aging with a focus on senescence immune surveillance and the development of cell-based senolytics.
Visit website: https://www.amorlab.org/people/
See also: Cold Spring Harbor Laboratory (CSH) - Biomedical research and education lab with programs in cancer, neuroscience, plant biology and quantitative biology
Details last updated 18-Jun-2020
The treated mice showed better health, including improved metabolism and activity
In mice, this therapy was shown to reduce the number of senescent cells
Tested successfully in mice with liver fibrosis and lung cancer