Clett completed his BSc in Molecular Biology (1997), and PhD in Molecular Immunology (2003), at the University of Edinburgh. He then moved to Strathclyde University to take up a British Heart Foundation sponsored Junior Research Fellowship. In 2008, he moved to the University of Leicester to take a second Research Fellowship. During this time, Clett’s research focus progressed from an exploration of the impact of oxidised lipids and lipoproteins on innate immune signalling, to the mechanisms by which pattern-recognition receptors regulate lipid metabolism at the cellular and systemic levels. Currently, his work focuses particularly on the mechanisms connecting pattern-recognition receptor signalling with the induction of risk factors for chronic metabolic disease.