The National Institutes of Health Common Fund’s Cellular Senescence Network Program was established to comprehensively identify and characterize the differences in senescent cells across the body, across various states of human health, and across the lifespan at single-cell resolution. 

SenNet deliverables will provide a sound platform to develop approaches for the betterment of human health. This will be achieved by:

• generating multimodal atlases that characterize the heterogeneity and spatial distribution of senescent cells in health and across the lifespan, at single cell resolution
• determining reliable biomarker panels to identify senescent cells as well as their secretory properties in vivo and/or ex vivo
• establishing the next generation of tools, and experimental and computational model systems amenable to perturbations, necessary to construct high resolution atlases of cellular senescence
• establishing parameters for regulating senescence, both at the level of inducers and their removal through senolytics, immune therapy, or other means
• dramatically improving imaging tools to identify and validate senescence at the cellular, tissue and whole-body levels