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Teeth-whitening lozenge that repairs & rebuilds enamel, enters clinical trials

Gene engineered peptide coats few micrometers of new enamel at a time

01-Mar-2021

Key points from article :

Researchers preparing clinical trials of a lozenge that contains a genetically engineered peptide, along with phosphorus and calcium ions.

Peptide is derived from amelogenin, a key protein in the formation of tooth enamel and cementum.

Binds to the damaged enamel to repair it while not affecting the mouth’s soft tissue.

Two lozenges a day can rebuild enamel, while one a day can maintain a healthy layer.

Can be used like a mint and is expected to be safe for use by adults and children.

Lozenge produces new enamel that is whiter than what tooth-whitening strips or gels produce.

“...seeing how the whitening effect compares to existing commercial treatments,” - Mehmet Sarikaya, team leader.

Already tested on extracted teeth from humans, pigs, and rats, and also on live rats.

Developing a toothpaste for OTC use.

Investigating a gel or solution to treat hypersensitive teeth.

The peptide addresses the problem permanently at its source by strengthening the enamel.

Research by University of Washington.

Mentioned in this article:

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Mehmet Sarikaya

Professor of Materials Science and Engineering, Chemical Engineering, and Oral Health Sciences at University of Washington

University of Washington (UW)

Public research university in Seattle, Washington

Topics mentioned on this page:
Dental Health