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Silver nanoparticles may overcome resistance in non-motile microbes


Key points from article :

One of the main drivers of antimicrobial resistance is the misuse and overuse of antimicrobial agents.

Silver nanoparticles demonstrate well-documented antimicrobial properties.

Researchers exposed E.coli to 20 consecutive days of silver nanoparticles and monitored bacterial growth.

"We found that bacteria could survive even at higher doses," - Lisa Stabryla, lead author.

"Some form of silver is getting into the cell, and the cell mutates to quickly pump it out," - Stabryla.

Only the hyper-motile strain of E.coli developed resistance.

"Silver nanoparticles may be a good option to target certain types of bacteria, particularly non-motile strains," - Stabryla.

Understanding the mechanisms and a mindful use of new antimicrobials will lessen the impact of antimicrobial resistance.

"Results are promising to tune particle properties for a desired response, such as high efficacy while avoiding resistance," - Leanne Gilbertson, Co-author.

Study by University of Pittsburgh published in Nature Nanotechnology.

Limiting misuse & designing potent nanoparticles offer a sustainable antimicrobial to the world

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Leanne Gilbertson

Researcher and Assistant Professor at University of Pittsburgh

Lisa Stabryla

Graduate Researcher and Teaching Assistant at University of Pittsburgh

Nature Nanotechnology

A journal providing information from all aspects of nanoscale science and technology.

University of Pittsburgh

Public state-related research university