Key points from article :
Interdisciplinary team of researchers from TU Dresden and Max Bergmann Center of Biomaterials developed novel bio-inspired molecules for bone regeneration.
The molecules are based on glycosaminoglycans, long-chained sugars like hyaluronic acid or heparin.
Computer modeling and simulations were used to design new molecules to interfere with proteins that block bone regeneration.
Materials containing these novel molecules outperformed standard biomaterials and enhanced bone healing in mice by up to 50%.
The multidisciplinary team used rational drug design, computational methods, and iterative testing to create molecules with tailored properties and minimal side effects.
The findings represent an exciting step forward in preclinical development and could lead to more effective treatments for bone fractures and other bone-related conditions.
The team aims to apply for funding for a pre-clinical study to further develop the molecules and biomaterial-based bone booster for human studies.
Research led by Prof. Lorenz Hofbauer at the Medical Faculty of TU Dresden published in Biomaterials.
