Programmable bacteria can be used to kill cancer cells
Scientists destroy tumours in mice using genetically reprogrammed bacteria.
Cancer cells produce CD47 protein to cloak cancer cells from immune cells that can destroy them.
Scientists introduced nanobodies into bacteria and injected those bacteria into mice.
Bacteria produced more nanobodies and released them in to tumours.
Nanobodies attached to CD47 proteins on cancer cells and exposed them to immune cells.
Potential to develop programmable bacteria to treat cancers without side effects in the future.
Research by Columbia University in New York, published in the journal Nature Medicine.
Mentioned in this article:
Michael Dougan - Assistant Professor of Medicine at Massachusetts General Hospital.
Nature Medicine - Scientific Journal providing information from all areas of medicine.
Nicholas Arpaia - Assistant Professor of Microbiology and Immunology at Columbia University.