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PAR plays a key role in hardening of the arteries


Key points from article :

Calcium deposits are triggered by a molecule, called poly (ADP-Ribose) or PAR.

PAR is produced when the cells, or the DNA inside them, are damaged.

Drug minocycline switch off PAR production and one day might help patients with arterial disease.

Development of PAR inhibitors might reduce the likelihood of heart attack and stroke.

The study was published in Cell Reports journal.

Study finds calcium deposits are triggered by a molecule produced by damaged cells

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Professor of Cellular Signalling at King's College London.


Journal publishing research papers across a broad range of disciplines within the life sciences.


Public research university


Senior Lecturer at University of Cambridge.