Key points from article :
Scientists developed a cancer-killing pill that kills solid tumors through targeted chemotherapy.
The AOH1996 molecule targets a cancerous variant of PCNA, a key protein to DNA replication and repair of enlarging tumors.
Preclinical research showed its effectiveness in treating breast, prostate, brain, ovarian, cervical, skin and lung cancers.
New study that tested the protein on over 70 cancer cell lines found that AOH1996 selectively killed cancer cells by disrupting the normal cell reproductive cycle.
Aiming to further the clinical trial in humans next stage.
“Our cancer-killing pill is like a snowstorm that closes a key airline hub, shutting down all flights in and out only in planes carrying cancer cells”, - Linda Malkas, professor in City of Hope’s Department of Molecular Diagnostics and Experimental Therapeutics.
"AOH1996 can suppress tumor growth as a monotherapy or combination treatment in cell and animal models without resulting in toxicity."
"The investigational chemotherapeutic is currently in a Phase 1 clinical trial in humans at City of Hope."
Research by the City of Hope, published in the journal Cell Chemical Biology.
