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Molecular destruction code found in an enzyme involved in cholesterol synthesis


Key points from article :

A key enzyme in the cholesterol synthesis pathway can be regulated and destroyed using a particular molecule.

Can be used to develop new drugs to lower cholesterol levels.

Cholesterol is mostly produced inside the human body, contribution from food is small.

The enzyme squalene monooxygenase in the cholesterol synthesis pathway has a destruction code.

Once the destruction code is unlocked a ubiquitin molecule can bind to it and destroy the enzyme.

Needs further research to unlock this code and to initiate enzyme destruction.

Research by University of New South Wales, published in the Journal of Biological Chemistry.

Could be used to develop more effective drugs to lower cholesterol levels

Mentioned in this article:

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Professor of Biochemistry in the School of Biotechnology and Biomolecular Sciences at UNSW.


Scientific Journal providing information about biological chemistry and similar disciplines.


PhD Student at UNSW.


Public Research university.