The university is made up of 9 teaching and administrative campuses in Ávila, Zamora, Béjar y Salamanca. Therefore, it is caracterised by its widely dispersed geography. In the city of Salamanca, the educational centres are grouped into six campuses: the Historical campus, Campus of Sciences, Campus de Canalejas, Campus Miguel de Unamuno (Campus of Bio(health/Sciences? and Campus of FES-Law), Campus Ciudad Jardín and Campus Villamayor.

The University of Salamanca is of medium size with 26,746 registered students in the first and second cycles of the 2006/07 course and 26,828 in the 2007/2008 course, (in nineteenth position among public universities (UUPP) according to the publication of CRUE, The Spanish University in Figures 2008). If we add to this figure the number of registered students in, University Masters, doctorate programmes and further studies, the figure surpasses 30,000 students.