Tolerance Bio focuses on restoring thymic function to address immune diseases caused by thymic involution, a process where the thymus deteriorates with age, leading to weakened immune tolerance. This degeneration results in increased risks for cancer, autoimmune diseases, and infections. Tolerance Bio aims to delay or prevent this thymic loss through stem cell-derived therapies and drugs that support thymus health. Their research includes creating functional thymic organoids from human pluripotent stem cells to regenerate immune function. These innovations have the potential to improve longevity and reduce immune-related diseases, making significant advancements in immunotherapy.