Thiel believes in the importance and desirability of a technological singularity. The Foundation has given over $1,627,000 to MIRI. In February 2006, Thiel provided $100,000 of matching funds to back the Singularity Challenge donation drive of the Machine Intelligence Research Institute (then known as the Singularity Institute for Artificial Intelligence). Additionally, he joined the Institute's advisory board and participated in the May 2006 Singularity Summit at Stanford as well as at the 2011 Summit held in New York City.

In May 2007, Thiel provided half of the $400,000 matching funds for the annual Singularity Challenge donation drive.

The organization was a participant in the Breakthrough Philanthropy conference (November 2010) and the Fast Forward conference (December 2011).