In this episode, Dr. Jennifer Garrison from the Buck Institute for Research on Aging, shared her expertise on reproductive ageing, neuropeptide signalling, and the under-researched science of menopause. Jennifer and Matt discussed misconceptions about hormone replacement therapy, the importance of the ovaries' endocrine function, and evolutionary perspectives on menopause. Dr. Garrison, who also co-founded Productive Health and holds academic appointments at UCSF and USC, is a recognized leader in her field with numerous prestigious awards and a strong academic background from UC San Francisco and UC Berkeley.

Key Points

Dr. Jennifer Garrison discussed about reproductive ageing, menopause, and hormone replacement therapy, highlighting the need for better understanding in medical curricula. She leads Productive Health and holds multiple prestigious awards and academic appointments.

• Reproductive ageing Research: Dr. Jennifer Garrison discussed her transition from studying neuropeptides to focusing on reproductive ageing, highlighting the role of bioactive peptides in the brain and their broader influence on physiology and ageing.
• Importance of the Endocrine Function of Ovaries: The podcast emphasized that ovaries do more than just support reproduction; they also play a crucial role in overall health by producing essential hormones, which decline significantly during menopause, leading to increased health risks.
• Evolutionary Perspective on Menopause: The discussion explored evolutionary questions surrounding menopause, including why only a few species experience it and its possible advantages, like the "grandmother hypothesis."
• Challenges in Women's Health: Dr. Garrison addressed the significant knowledge gap in reproductive ageing and the lack of proper education and training in medical schools regarding women's health, particularly around menopause and hormone replacement therapy.
• Hormone Replacement Therapy (HRT): The conversation highlighted the controversies and misconceptions around HRT, particularly following the Women's Health Initiative (WHI) study, and argued for a more proactive approach in starting HRT to improve long-term health outcomes.
• Innovative Research and Interventions: Dr. Garrison discussed cutting-edge research funded by her organization, such as exploring the mechanical properties of ovaries and the potential of non-invasive techniques to monitor ovarian ageing, as well as the need for more personalized and advanced hormone therapies.