The research of Sundeep Khosla, M.D., focuses on the mechanisms of age-related bone loss, sex steroid regulation of bone metabolism and the detrimental effects of diabetes mellitus on bone. Dr. Khosla's research group in his Osteoporosis and Bone Biology Laboratory is examining how fundamental aging mechanisms in bone lead to increased skeletal fragility. In addition, Dr. Khosla also uses a number of genetically engineered disease models to define how estrogen regulates the skeleton. In clinical studies, Dr. Khosla is examining the adverse effects of type 2 diabetes mellitus on bone structure and material properties, which may explain the increase in fracture risk in this population.

Focus areas

• Mechanisms of age-related bone loss
• Sex steroid action on bone
• Effects of diabetes mellitus on bone