Sir Charles Gairdner Hospital (SCGH) is a teaching hospital in Nedlands, Western Australia.

Opened in 1958 as the Perth Chest Hospital and later named in honour of Sir Charles Gairdner, governor of Western Australia from 1951 to 1963, it is part of the Queen Elizabeth II Medical Centre (QEII MC). It is colloquially referred to as Charlie's.

All clinical specialities are provided, with the exception of complex burns, paediatrics, obstetrics, gynaecology and major trauma. It houses the state's only comprehensive cancer treatment centre, and is the state's principal hospital for neurosurgery and liver transplants. The hospital is closely associated with the nearby University of Western Australia as well as Curtin University, Notre Dame University, and Edith Cowan University.