Sarah Crunkhorn studied for her BSc at the University of Sheffield where she obtained a first in pharmacology. Following her doctoral research in molecular toxicology at the University of Surrey in collaboration with GlaxoSmithKline, where she investigated mechanisms mediating xenobiotic-induced liver growth, she moved to the Joslin Diabetes Centre, Harvard Medical School, Boston, USA, for her postdoctoral research. There she carried out studies aimed to identify novel molecular mechanisms of thiazolidinedione action in humans, and explored the mechanistic role of obesity and overnutrition in modulating muscle gene expression important in the pathophysiology of insulin resistance and type 2 diabetes. She joined Nature Reviews Drug Discovery as an Associate Editor in May 2007. Sarah is based in Boston, USA.