His laboratory initially focused on skeletal muscle injury and changes to the sarcolemmal-associated proteins in skeletal muscle fibers. Many of the changes induced by injury parallel the changes that occur with muscular dystrophy and sarcopenia (aging muscle), which have become the focus of the laboratory in recent years. They try to relate changes seen at the cell level to whole muscle function and non-invasive in vivo imaging, such as MR imaging and spectroscopy. They are actively exploring interventions to minimize the weakness and susceptibility to injury observed in aging and dystrophic muscles. Their most recent efforts have been focused on elucidating changes in nuclear mobility, position, and function that occur in dystrophic and aging muscles, and relating these findings to the muscle fiber cytoskeletal architecture and overal muscle function.