Reprogrammed tumour cells to be used as therapeutic cancer vaccine for treating cancer
Stanford School of Medicine - 01-Mar-2023T cells are trained to recognize cancer antigens, which attack the cancer cells when reintroduced into the body
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Director of the Institute for Stem Cell Biology and Regenerative Medicine at the Stanford University School of Medicine.
Ravi Majeti MD, PhD is Professor of Medicine, Division of Hematology, and Director of the Institute for Stem Cell Biology and Regenerative Medicine at the Stanford University School of Medicine. He was an undergraduate at Harvard, earned his MD and PhD from UCSF, and trained in Internal Medicine at Brigham and Women’s Hospital in Boston. Dr. Majeti completed his Hematology Fellowship at Stanford, and is a board-certified hematologist. While at Stanford, he completed post-doctoral training in the laboratory of Irving Weissman, where he investigated acute myeloid leukemia (AML) stem cells and therapeutic targeting with anti-CD47 antibodies.
With Dr. Weissman, he developed a humanized anti-CD47 antibody, initiated first-in-human clinical trials. Dr. Majeti directs an active NIH-funded laboratory that focuses on the molecular characterization and therapeutic targeting of leukemia stem cells in human hematologic disorders, particularly AML, and has published >100 peer-reviewed articles. He is a recipient of the Burroughs Wellcome Career Award for Medical Scientists, the New York Stem Cell Foundation Robertson Investigator Award, and the Leukemia and Lymphoma Society Scholar Award.
Dr. Majeti is currently a member of the Committee on Scientific Affairs for the American Society of Hematology (ASH) and serves of the editorial board of Blood and eLife.
The Majeti lab focuses on the molecular/genomic characterization and therapeutic targeting of leukemia stem cells in human hematologic malignancies, particularly acute myeloid leukemia (AML). In parallel, the lab also investigates normal human hematopoiesis and hematopoietic stem cells. Our lab uses experimental hematology methods, stem cell assays, genome editing, and bioinformatics to define and investigate drivers of leukemia stem cell behavior. As part of these studies, we have led the development and application of robust xenotransplantation assays for both normal and malignant human hematopoietic cells. A major focus of the lab is the investigation of pre-leukemic hematopoietic stem cells in human AML.
Visit website: https://profiles.stanford.edu/ravindra-majeti
See also: Stanford University School of Medicine - Medical school that improves health through discoveries and innovation in health care, education and research
Details last updated 14-Mar-2023
T cells are trained to recognize cancer antigens, which attack the cancer cells when reintroduced into the body