Our lab focuses on studying alterations of the extracellular matrix (ECM) in cancer as well as in connective tissue disorders. To this end, we use Second Harmonic Generation imaging microscopy for imaging structural aspects of tissues, where the approaches will ultimately be implemented as clinical diagnostics. We also use 3D nano/microfabrication approaches to create biomimetic models of the ECM to study signaling pathways associated with cancer and also to provide insight into the design of tissue engineering scaffolds.