Nikolaus Rajewsky is a German systems biologist at the Max-Delbrück-Center for Molecular Medicine (MDC) and at the Charité in Berlin. He founded and directs the “Berlin Institute for Medical Systems Biology”. (BIMSB, Max-Delbrück-Center for Molecular Medicine). He leads the Rajewsky lab, where he studies how RNA regulates gene expression. He also co-chairs “LifeTime", a pan-European research initiative of more than 90 academic institutions and 70 companies, which aims to revolutionize healthcare by mapping, understanding, and targeting cells during disease progression. LifeTime integrates several technologies: single-cell multiomics, machine learning, and personalized disease models such as organoids. Rajewsky has received numerous awards and honors, including the most prestigious German award, the Gottfried Wilhelm Leibniz Prize, endowed with 2.5 million euros by the German Research Foundation (DFG).