Crichton graduated summa cum laude from Harvard College, received his MD from Harvard Medical School, and was a postdoctoral fellow at the Salk Institute for Biological Studies, researching public policy with Jacob Bronowski. He taught courses in anthropology at Cambridge University and writing at MIT. Crichton’s 2004 bestseller, State of Fear, acknowledged the world was growing warmer, but challenged extreme anthropogenic warming scenarios. He predicted future warming at 0.8 degrees C. (His conclusions have been widely misstated.)

Crichton’s interest in computer modeling went back forty years. His multiple-discriminant analysis of Egyptian crania, carried out on an IBM 7090 computer at Harvard, was published in the Papers of the Peabody Museum in 1966. His technical publications included a study of host factors in pituitary chromophobe adenoma, in Metabolism, and an essay on medical obfuscation in the New England Journal of Medicine.